HOW PESC WORKS
WHAT IS PESC?
Every one of us is a collection of over 30 trillion cells. Every one of these cells comes from a single pluripotent type of cell called a stem cell. Stem cells have already changed medicine forever and while they have the ability to extend our lives now they will undoubtedly be saving lives in the near future.
When we are conceived, a single nondescript cell with a giant nucleus cytoplasm and a cell membrane goes on to replicate and create every single cell in the body. This lone cell has all the genetic code and the biological software it needs to produce everything that defines every specialised cell in the body.
The inherent intelligence of stem cells means they have the ability to differentiate into any other type of cell in the body. They have been called 'nature's perfect repair kit - ready to mobilise and facilitate repair when needed.'
At ReGen we are carefully harnessing that intelligence to replicate, heal and regrow soft tissue namely cartilage that has been eroded or been depleted through the course of our lives. Science has shown these cells can be woken up by the reintroduction of new healing mesenchymal (MSC) cells. These MSCs release cytokines which are signaling molecules which prime the cells for repair and rejuvenation.
At ReGen we use proprietary protocols which allow us to create a serum from your own body fat that has the largest concentration of MSCs on the market today.
This serum, when mixed with the patient’s own Platelet Rich Plasma, gives the body the best chance of regrowing and repairing damaged cartilage.
THE PESC PROCESS
Consult with ReGen specialist
Dr Mubark will review all medical files, medical history and examine you to ascertain suitability and likely success of treatment. Not all patients are suitable for PESC therapy.
Harvesting the Stem Cells
PESC is a solution which is 95% pure stem cells derived from a patient’s own fatty tissues which is a store of Mesenchymal Stem Cells – MSCs which are the healing cells. At ReGen we only use a patient’s own adult stem cells (autologous) which include these MSCs.
A minor liposuction procedure done under local anesthetic is carried out to extract 40 grams or one teaspoon of fat.
This procedure takes around an hour.
Expanding the Stem Cells
PESC therapy is not a same-day procedure. After extraction, growing or multiplying the cells in our Queenstown laboratory under strict protocols takes around 8 weeks. The resulting sample is 95% pure mesenchymal stem cells with a yield of between 100 million and 200 million cells. A mesenchymal stromal cell has the ability to;
- Reduce inflammation
- Reduce cell death (Apoptosis)
- Differentiate into multiple tissues – bone, muscle, fat, cartilage
Cryo-frozen Stem Cells for Future Use
The expanded stem cells are then cryogenically frozen until your procedure.
We produce many more stem cells than are needed as this gives our clients the bonus of storing these for later use.
The additional stem cells can be cryogenically frozen indefinitely and used for other damaged joints in the future. The advantage of this is that no further fat has to be extracted and “younger” stem cells have a greater ability to affect healing later in life.
Larger joints such as knees, hips or shoulders 50-100 million stem cells are used. Our doctors will inject a maximum of two large joints per session. For smaller joints such as elbows, ankles or wrists 25-50 million cells will be used. A maximum of two medium joints per session can be treated.
The injecting doctor will take a blood sample which will be spun in a centrifuge to create Platelet Rich Plasma (PRP). Platelets are the cells that are attracted to wound sites where they release cytokines and stimulate the healing and regeneration process. This takes around 15 minutes.
The PRP is then mixed with PESC to protect the MSC’s as well as conditioning the MSC’s to be more effective at the injury site.
Under ultrasound guidance, the Doctor then administers local anesthetic into the joint and then a short time later the PESC/PRP solution is injected.
Patients are given a prescription for pain relief but are able to leave immediately.